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Reinforcing this, a prior study elucidated the surge in MDA, coupled with a concomitant drop in antioxidants like GSH and SOD, in cardiac tissues under the duress of CLP-induced sepsis 50

PDCs were characterized by disparate EGFR/PTEN status, MGMT methylation state, molecular subtype, invasive characteristics in mouse orthotopic xenografts (0: low, 7: hi), and sensitivity to erlotinib (0: not sensitive, 100: sensitive) ( Figure 2A )

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The downregulation of both MMP-2 and MMP-9 delays the epithelial-mesenchymal transition (EMT) because this inhibition reduces the capacity of osteosarcoma cells to degrade the ECM, migrate, and infiltrate tissues by 40% to 70% 64,65